Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in VitroComparative Biochemistry and Physiology Part C: Comparative Pharmacology
Abstract1. The present study has evaluated, in vitro, alpha 1-adrenergic receptor mediated responses in submandibular cells from young adult and aged rats. 2. Submandibular glands from different aged rats possess a similar number of alpha 1-adrenergic receptors that display comparable binding characteristics. 3. Following alpha 1-adrenergic stimulation, cells from both groups of rats show a similar ability to mobilize intracellular Ca2+ (45Ca2+ time course, agonist dose-response) and to elicit a functional response (inhibition of protein synthesis by epinephrine) which reflects Ca2+ mobilization.
- submandibular gland,
Citation InformationB. J. Baum, Brian L. Kuyatt, Y. Helman, M. V. Gee, et al.. "Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro" Comparative Biochemistry and Physiology Part C: Comparative Pharmacology Vol. 81C Iss. 1 (1985) p. 121 - 124 ISSN: 0742-8413
Available at: http://works.bepress.com/brian_kuyatt/25/