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Article
Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro
Comparative Biochemistry and Physiology Part C: Comparative Pharmacology
  • B. J. Baum
  • Brian L. Kuyatt, Cedarville University
  • Y. Helman
  • M. V. Gee
  • G. S. Roth
Document Type
Article
Publication Date
1-1-1985
DOI
http://dx.doi.org/10.1016/0742-8413(85)90101-x
Abstract
1. The present study has evaluated, in vitro, alpha 1-adrenergic receptor mediated responses in submandibular cells from young adult and aged rats. 2. Submandibular glands from different aged rats possess a similar number of alpha 1-adrenergic receptors that display comparable binding characteristics. 3. Following alpha 1-adrenergic stimulation, cells from both groups of rats show a similar ability to mobilize intracellular Ca2+ (45Ca2+ time course, agonist dose-response) and to elicit a functional response (inhibition of protein synthesis by epinephrine) which reflects Ca2+ mobilization.
Keywords
  • Adrenergic,
  • submandibular gland,
  • rats,
  • calcium,
  • epinephrine,
  • prazosin,
  • receptors
Comments

Journal currently known as Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology

PubMed ID
2861036
Citation Information
B. J. Baum, Brian L. Kuyatt, Y. Helman, M. V. Gee, et al.. "Alpha 1-Adrenergic Responsiveness of Young Adult and Aged Rat Submandibular Cells in Vitro" Comparative Biochemistry and Physiology Part C: Comparative Pharmacology Vol. 81C Iss. 1 (1985) p. 121 - 124 ISSN: 0742-8413
Available at: http://works.bepress.com/brian_kuyatt/25/