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Clinical and Experimental Applications of NIR-LED Photobiomodulation
Photomedicine and Laser Surgery
  • Kristina D. Desmet, University of Wisconsin - Milwaukee
  • David A. Paz, Medical College of Wisconsin
  • Jesse J. Corry, Medical College of Wisconsin
  • Janis T. Eells, University of Wisconsin - Milwaukee
  • Margaret T. T. Wong-Riley, Medical College of Wisconsin
  • Michele M. Henry, Medical College of Wisconsin
  • Ellen V. Buchmann, Medical College of Wisconsin
  • Mary P. Connelly, Medical College of Wisconsin
  • Julia V. Dovi, Medical College of Wisconsin
  • Huan Ling Liang, Medical College of Wisconsin
  • Diane S. Henshel, Indiana University - Bloomington
  • Ronnie L. Yeager, Indiana University - Bloomington
  • Deborah S. Millsap, Indiana University - Bloomington
  • Jinhwan Lim, Indiana University - Bloomington
  • Lisa J. Gould, Medical College of Wisconsin
  • Rina Das, Walter Reed Army Institute of Research
  • Marti Jett, Walter Reed Army Institute of Research
  • Brian D. Hodgson, Marquette University
  • David Margolis, Medical College of Wisconsin
  • Harry T. Whelan, Medical College of Wisconsin
Document Type
Format of Original
8 p.
Publication Date
Mary Ann Liebert Inc.
Original Item ID
doi: 10.1089/pho.2006.24.121

This review presents current research on the use of far-red to near-infrared (NIR) light treatment in various in vitro and in vivo models. Low-intensity light therapy, commonly referred to as “photobiomodulation,” uses light in the far-red to near-infrared region of the spectrum (630–1000 nm) and modulates numerous cellular functions. Positive effects of NIR–light-emitting diode (LED) light treatment include acceleration of wound healing, improved recovery from ischemic injury of the heart, and attenuated degeneration of injured optic nerves by improving mitochondrial energy metabolism and production. Various in vitro and in vivo models of mitochondrial dysfunction were treated with a variety of wavelengths of NIR-LED light. These studies were performed to determine the effect of NIR-LED light treatment on physiologic and pathologic processes. NIRLED light treatment stimulates the photoacceptor cytochrome c oxidase, resulting in increased energy metabolism and production. NIR-LED light treatment accelerates wound healing in ischemic rat and murine diabetic wound healing models, attenuates the retinotoxic effects of methanol-derived formic acid in rat models, and attenuates the developmental toxicity of dioxin in chicken embryos. Furthermore, NIR-LED light treatment prevents the development of oral mucositis in pediatric bone marrow transplant patients. The experimental results demonstrate that NIR-LED light treatment stimulates mitochondrial oxidative metabolism in vitro, and accelerates cell and tissue repair in vivo. NIR-LED light represents a novel, noninvasive, therapeutic intervention for the treatment of numerous diseases linked to mitochondrial dysfunction.


Published version. Photomedicine and Laser Surgery, Volume 24, No. 2 (2006), DOI. © 2006 Mary Ann Liebert Inc. Used with permission.

This is a copy of an article published in the Photomedicine and Laser Surgery © 2006 Mary Ann Liebert, Inc.; Photomedicine and Laser Surgery is available online at:

Brian Hodgson was affiliated with Children's Hospital of Wisconsin at the time of publication.

Citation Information
Kristina D. Desmet, David A. Paz, Jesse J. Corry, Janis T. Eells, et al.. "Clinical and Experimental Applications of NIR-LED Photobiomodulation" Photomedicine and Laser Surgery (2006) ISSN: 1549-5418
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