Skip to main content
Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy
  • Janis T. Eells, University of Wisconsin - Milwaukee
  • Margaret T. T. Wong-Riley, Medical College of Wisconsin
  • James VerHoeve, University of Wisconsin - Madison
  • Michele M. Henry, Medical College of Wisconsin
  • Ellen V. Buchmann, Medical College of Wisconsin
  • Mary P Kane, Medical College of Wisconsin
  • Lisa J Gould, University of Texas Medical Branch
  • Rina Das, Walter Reed Army Institute of Research
  • Marti Jett, Walter Reed Army Institute of Research
  • Brian Hodgson, Marquette University
  • David Margolis
  • Harry T Whelan, Medical College of Wisconsin
Document Type
Format of Original
9 p.
Publication Date
Photobiomodulation by light in the red to near infrared range (630–1000 nm) using low energy lasers or light-emitting diode (LED) arrays has been shown to accelerate wound healing, improve recovery from ischemic injury in the heart and attenuate degeneration in the injured optic nerve. Recent evidence indicates that the therapeutic effects of red to near infrared light result, in part, from intracellular signaling mechanisms triggered by the interaction of NIR light with the mitochondrial photoacceptor molecule cytochrome c oxidase. We have demonstrated that NIR-LED photo-irradiation increases the production of cytochrome oxidase in cultured primary neurons and reverses the reduction of cytochrome oxidase activity produced by metabolic inhibitors. We have also shown that NIR-LED treatment prevents the development of oral mucositis in pediatric bone marrow transplant patients. Photobiomodulation improves wound healing in genetically diabetic mice by upregulating genes important in the promotion of wound healing. More recent studies have provided evidence for the therapeutic benefit of NIR-LED treatment in the survival and functional recovery of the retina and optic nerve in vivo after acute injury by the mitochondrial toxin, formic acid generated in the course of methanol intoxication. Gene discovery studies conducted using microarray technology documented a significant upregulation of gene expression in pathways involved in mitochondrial energy production and antioxidant cellular protection. These findings provide a link between the actions of red to near infrared light on mitochondrial oxidative metabolism in vitro and cell injury in vivo. Based on these findings and the strong evidence that mitochondrial dysfunction is involved in the pathogenesis of numerous diseases processes, we propose that NIR-LED photobiomodulation represents an innovative and non-invasive therapeutic approach for the treatment of tissue injury and disease processes in which mitochondrial dysfunction is postulated to play a role including diabetic retinopathy, age-related macular degeneration, Leber's hereditary optic neuropathy and Parkinson's disease.

Mitochondrion, Volume 4, Issues 5-6, pp 559-567 (September, 2004). DOI.

Citation Information
Janis T. Eells, Margaret T. T. Wong-Riley, James VerHoeve, Michele M. Henry, et al.. "Mitochondrial signal transduction in accelerated wound and retinal healing by near-infrared light therapy" Mitochondrion (2004) ISSN: 1567-7249
Available at: