Article
Microbes and Alzheimer's Disease
Journal of Alzheimer's Disease
(2016)
Abstract
We are researchers and clinicians working on
Alzheimer’s disease (AD) or related topics, and we
write to express our concern that one particular aspect
of the disease has been neglected, even though treatment
based on it might slow or arrest AD progression.
We refer to the many studies, mainly on humans,
implicating specific microbes in the elderly brain,
notably herpes simplex virus type 1 (HSV1),Chlamydia
pneumoniae, and several types of spirochaete, in
the etiology of AD. Fungal infection of AD
brain has also been described, as well as abnormal
microbiota in AD patient blood. The first
observations of HSV1 in AD brain were reported
almost three decades ago. The ever-increasing
number of these studies (now about 100 on HSV1
alone) warrants re-evaluation of the infection and AD
concept.
Keywords
- alzheimer's Disease,
- Chlamydia pneumonia,
- infectious disease
Disciplines
Publication Date
April, 2016
DOI
10.3233/JAD-160152
Publisher Statement
Copyright © 2016 IOS Press.
Citation Information
Ruth Itzhaki, Richard Lathe, Brian J. Balin, Melvyn J. Ball, et al.. "Microbes and Alzheimer's Disease" Journal of Alzheimer's Disease Vol. 51 Iss. 4 (2016) p. 979 - 984 Available at: http://works.bepress.com/brian_balin/70/