Article
Genetics of Opiate Addiction
Current Psychiatry Reports
(2014)
Abstract
Addiction to MOP-r agonists such as heroin (and also addiction to prescription opioids) has reemerged as an epidemic in the twenty first century, causing massive morbidity. Understanding the genetics contributing to susceptibility to this disease is crucial for the identification of novel therapeutic targets, and also for discovery of genetic markers which would indicate relative protection or vulnerability from addiction, and relative responsiveness to pharmacotherapy. This information could thus eventually inform clinical practice. In this review, we focus primarily on association studies of heroin and opiate addiction, and further describe the studies which have been replicated in this field, and are thus more likely to be useful for translational efforts.
Disciplines
Publication Date
September 11, 2014
DOI
10.1007/s11920-014-0504-6
Citation Information
Brian Reed, Eduardo R. Butelman and Vadim Yuferov. "Genetics of Opiate Addiction" Current Psychiatry Reports Vol. 16 (2014) p. 504 Available at: http://works.bepress.com/brian-reed-CHEM/22/