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About Brian D. Piening, PhD

Dr. Piening serves as Technical Director for clinical genomics at Providence, where he and the team utilize comprehensive genomic profiling to develop personalized treatment plans for patients with advanced cancer. Dr. Piening also runs a research laboratory at the Earle A. Chiles Research Institute at Providence that utilizes integrative multi-omics approaches develop new methods for predicting which therapies will succeed or fail based upon a patient's unique molecular tumor profile. Dr. Piening performed his doctoral training in Molecular and Cellular Biology at the University of Washington and Fred Hutchinson Cancer Research Center and his postdoctoral training in Genetics at Stanford University.

Positions

2020 - Present Affiliate Assistant Professor, University of Washington ‐ Bioinformatics and Medical Education
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2019 - Present Technical Director, Providence ‐ Clinical Genomics
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2018 - Present Assistant Member and Chief, Providence ‐ Earle A. Chiles Research Institute - Cancer Immunogenomics
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2016 - 2019 Associate Director, Providence Health & Services ‐ Clinical Genomics
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Disciplines

Grants

2021 - Present Master Data Sharing Agreement
Illumina Inc.
Role: PI
2020 - Present Applying machine learning techniques on routinely collected breast cancer data to improve patient outcomes
University of Chicago
Nightingale Grant Agreement
Role: Co-PI
2020 - Present Characterization of Novel Fusions in Glioblastoma
UCSF
Role: PI
2020 - Present Genomic and Clinical Characterization of SARS-CoV-2 virus in COVID-19 Patients at Providence
Collins Medical Trust
Role: PI
2020 - Present Machine-learning-based identification and quantification of immune cell content from multiplex immunofluorescence histopathology images in the neoadjuvant immunoradiotherapy (NIRT) cohort
Providence Cancer Institute
Developmental Research Program Grant
Role: PI
2020 - Present Multi-omic Biomarker Discovery and Validation in Heart Transplant Patient Populations
NIH/University of Pennsylvania - 1R01AI144522-01A1
Role: PI
2020 - Present Multi-omic characterization of brain tumor biospecimens
Swedish Health Services
Role: PI
2019 - Present Molecular Characterization of Response Mechanisms to HS-110 in Tumors
Heat Biologics
Role: PI
2019 - Present Rewiring the myeloid cell response to adjuants to improve tumor control
NIH - 1 R01 CA244142-02
Role: Co-Investigator
2018 - Present Immunotherapy Biomarker Detection Using nSMOL Technology
Shimadzu
Role: PI
2020 - 2021 Multi-omic Profiling in Health and Disease
University of Pennsylvania
Role: PI
2014 - 2016 Personal Omics Profiling of the Progression to Diabetes Mellitus Type 2
NIH/NIDDK - 1F32DK100072-01A1
Role: PI
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Honors and Awards

  • Mary Gates Undergraduate Research Scholarship 2003-2004
  • Amgen Interdisciplinary Fellowship 2008-2009
  • Department of Defense Breast Cancer Research Program Predoctoral Fellowship 2009-2013
  • Stanford Cardiovascular Institute Postdoctoral Fellowship (T32) 2013-2014

Education

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2013 - 2016 Postdoctoral Fellow, Stanford University School of Medicine ‐ Department of Genetics, Stanford Center for Genomics and Personalized Medicine
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2013 Ph.D., Molecular/Cellular Biology, University of Washington ‐ University of Washington and Fred Hutchinson Cancer Research Center
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2003 B.S., Physics; Astronomy (Dual Major), University of Washington
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Links

ORCID

Research Works (52)