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Article
The Analysis of Cyanide and its Breakdown Products in Biological Samples
Critical Reviews in Analytical Chemistry
  • Brian A. Logue, South Dakota State University
  • Diane M. Hinkens, South Dakota State University
  • Steven I. Baskin, US Army Medical Research Institute
  • Gary A. Rockwood, US Army Medical Research Institute
Document Type
Article
Publication Date
1-1-2010
Keywords
  • cyanide,
  • thiocyanate,
  • 2-amino-2-thiazoline-4-carboxylic acid (ATCA),
  • chemical warfare agent,
  • exposure,
  • toxicology,
  • analytical methods
Disciplines
Abstract

Cyanide is a toxic chemical that may be introduced into living organisms as a result of natural processes and/or anthropogenic uses (legal or illicit). Exposure to cyanide can be verified by analysis of cyanide or one of its breakdown products from biological samples. This verification may be important for medical, law-enforcement, military, forensic, research, or veterinary purposes. This review will discuss current bioanalytical techniques used for the verification of cyanide exposure, identify common problems associated with the analysis of cyanide and its biological breakdown products, and briefly address the metabolism and toxicokinetics of cyanide and its breakdown products in biological systems.

Pages
26
Format
application/pdf
Language
en
DOI of Published Version
10.1080/10408340903535315
Publisher
Taylor and Francis
Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S.
Citation Information
Brian A. Logue, Diane M. Hinkens, Steven I. Baskin and Gary A. Rockwood. "The Analysis of Cyanide and its Breakdown Products in Biological Samples" Critical Reviews in Analytical Chemistry Vol. 40 Iss. 2 (2010) p. 122 - 147
Available at: http://works.bepress.com/brian-logue/39/