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Article
Organ-distribution of the Metabolite 2-Aminothiazoline-4-Carboxylic Acid in a Rat Model following Cyanide Exposure
Biomarkers
  • Ilona Petrikovics, South Dakota State University
  • David E. Thompson, Sam Houston State University
  • Gary A. Rockwood, US Army Medical Research Institute of Chemical Defense
  • Brian A. Logue, South Dakota State University
Document Type
Article
Publication Date
12-1-2011
Disciplines
Abstract

The reaction of cyanide (CN−) with cystine to produce 2-aminothiazoline-4-carboxylic acid (ATCA) is one of the independent detoxification pathways of cyanide in biological systems. In this report, in vivo production of ATCA and its distributions in plasma and organs were studied after a subcutaneous sublethal dose of 4 mg/kg body weight potassium cyanide (KCN) administration to rats. At this sublethal dose of KCN, ATCA concentration was not significantly increased in the plasma samples, however, it was found significantly increased in liver samples. These results suggested that ATCA might not be a good diagnostic biomarker in plasma for sublethal cyanide exposure; however, liver could serve as the right organ for the detection of ATCA in post-mortem examinations involving cyanide exposure in military, firefighting, industrial and forensic settings.

DOI of Published Version
10.3109/1354750X.2011.626528
Publisher
Taylor and Francis
Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S.
Citation Information
Ilona Petrikovics, David E. Thompson, Gary A. Rockwood and Brian A. Logue. "Organ-distribution of the Metabolite 2-Aminothiazoline-4-Carboxylic Acid in a Rat Model following Cyanide Exposure" Biomarkers Vol. 16 Iss. 8 (2011) p. 686 - 690
Available at: http://works.bepress.com/brian-logue/27/