Since the reactive strength index (RSI) and reactive strength index-modified (RSI-mod) share similar nomenclature, they are commonly referred as interchangeable measures of agility in the sports research literature. The RSI and RSI-mod are most commonly derived from the performance of depth jumping (DJ) and countermovement jumping (CMJ), respectively. Given that DJ and CMJ are plyometric movements that differ materially from biomechanical and neuromotor perspectives, it is likely that the RSI and RSI-mod measure distinct aspects of neuromuscular function. The purpose of this investigation was to evaluate the association and agreement between RSI and RSI-mod scores. A mixed-sex sample of NCAA division I basketball athletes (n = 21) and active young adults (n = 26) performed three trials of DJ from drop heights of 0.51, 0.66, and 0.81 m and three trials of countermovement jumping. Using 2-dimensional videography and force platform dynamometry, RSI and RSI-mod scores were estimated from DJ and CMJ trials, respectively. Linear regression revealed moderate associations between RSI and RSI-mod scores (F = 11.0–38.1; R2 = 0.20–0.47; p < 0.001–0.001). Bland–Altman plots revealed significant measurement bias (0.50–0.57) between RSI and RSI-mod scores. Bland–Altman limit of agreement intervals (1.27–1.51) were greater than the mean values for RSI (0.97–1.05) and RSI-mod (0.42) scores, suggesting poor agreement. Moreover, there were significant performance-dependent effects on measurement bias, wherein the difference between and the mean of RSI and RSI-mod scores were positively associated (F = 77.2–108.4; R2 = 0.63–0.71; p < 0.001). The results are evidence that the RSI and RSI-mod cannot be regarded as interchangeable measures of reactive strength.