Relatively few investigations have examined the transfer effects of multiple-joint isokinetic eccentric only (MJIE) resistance training on non-specific measures of muscle strength. This study investigated the transfer effects of a short-term MJIE leg press (Eccentron) resistance training program on several non-specific measures of lower-body strength. Fifteen participants performed Eccentron training three times/week for four weeks and were evaluated on training-specific Eccentron peak force (EccPF), nontraining-specific leg press DCER one-repetition maximum (LP 1 RM), and peak torques of the knee extensors during isokinetic eccentric (Ecc30), isokinetic concentric (Con150) and isometric (IsomPT) tasks before and after the training period. The training elicited a large improvement in EccPF (37.9%; Cohen's d effect size [ES] = 0.86). A moderate transfer effect was observed on LP 1 RM gains (19.0%; ES = 0.48) with the magnitude of the strength improvement being about one-half that of EccPF. A small effect was observed on IsomPT and Ecc30 (ES = 0.29 and 0.20, respectively), however, pre-post changes of these measures were not significant. Con150 testing showed no effect (ES = 0.04). These results suggest a short term MJIE training program elicits a large strength improvement in training-specific measures, a moderate strength gain transfer effect to DCER concentric-based strength of a similar movement (i.e., LP 1 RM), and poor transfer to single-joint knee extension measures.