This article evaluates the potential for rebuilding tertiary education in Guinea-Bissau focusing on the reconstitution of the Universidade Amílcar Cabral, the operations of Universidade Lusófona da Guiné, and the development of the Bissau Campus Project through the West African Vocational Schools (WAVS) project. The article considers available resources and contextual constraints in the face of underdevelopment, structural violence, neo-colonialism, and a context-specific educational legacy. In the face of considerable barriers to rebuilding tertiary education in Guinea-Bissau, how can it be done? Achievements in other contexts, and specific recommendations for Guinea-Bissau, are aggregated to demonstrate how collaborating stakeholders can amalgamate knowledge and develop viable educational programs that are contextually sensitive, appropriate, and sustainable.