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Immunohistochemical localization of prostaglandin H synthase in the female reproductive tract and endometriosis
American Journal of Obstetrics and Gynecology
  • Bradley J. Van Voorhis, University of Iowa
  • P. C. Huettner
  • M. R. Clark
  • J. A. Hill
Document Type
Peer Reviewed
Publication Date
NLM Title Abbreviation
Am J Obstet Gynecol
PubMed ID

Prostaglandin H synthase, also known as cyclooxygenase, is an essential enzyme in prostaglandin synthesis. Using a monoclonal antibody and immunohistochemical techniques, we studied the localization of this enzyme in the female reproductive tract and in endometriosis. In the uterus, prostaglandin H synthase was primarily localized to endometrial epithelium with surface epithelium containing more immunoreactive prostaglandin H synthase than glandular epithelium. Fallopian tube secretory epithelial cells also contained prostaglandin H synthase while ciliated epithelial cells did not. Cervical epithelium and myometrial cells did not contain prostaglandin H synthase. A higher percentage of glands in endometriosis and adenomyosis, as compared with eutopic endometrium, contained prostaglandin H synthase suggesting that these tissues are also capable of prostaglandin synthesis. These findings may have important physiologic significance in the mechanisms of embryo implantation, in menstruation, and in the pathophysiologic features of endometriosis.

  • Adult,
  • Cervix Uteri/enzymology,
  • Endometriosis/enzymology/pathology,
  • Endometrium/enzymology/pathology,
  • Fallopian Tubes/enzymology,
  • Female,
  • Genitalia,
  • Female/enzymology,
  • Humans,
  • Immunohistochemistry/methods,
  • Middle Aged,
  • Prostaglandin-Endoperoxide Synthases/metabolism,
  • Staining and Labeling,
  • Tissue Distribution
Published Article/Book Citation
American Journal of Obstetrics and Gynecology, 163:1 Pt 1 (1990) pp.57-62.
Citation Information
Bradley J. Van Voorhis, P. C. Huettner, M. R. Clark and J. A. Hill. "Immunohistochemical localization of prostaglandin H synthase in the female reproductive tract and endometriosis" American Journal of Obstetrics and Gynecology Vol. 163 Iss. 1 Pt 1 (1990) p. 57 - 62 ISSN: 0002-9378
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