Classical and emerging persistent organic pollutants are of great concern due their negative effects on the environment, wildlife and human health. Estuaries and coastal marine environments are considered the most sensitive areas to the accumulation of these pollutants. The objective of this study was to understand the contamination status of classical and emerging pollutants in the rivers and estuarine waters of Savannah, Georgia. PCB congeners, chlorinated pesticides and PBDEs were analyzed in sediment and various fish species samples collected from the Vernon River, and other estuarine/brackish waters in the region. Standard analytical procedures were followed to determine the concentrations of these contaminants. Results revealed that detectable levels of PCBs, chlorinated pesticides and PBDEs were found in sediments and fish samples analyzed. Although several of the organochlorines were banned from production and use decades ago, residues of these compounds are still found in sediments and fish samples from Savannah, Georgia. PCBs and pesticides concentrations in fish tissues were below the Food and Drug Administration (FDA) established limits for human consumption. In addition, comparison of the geographical and historical data revealed that sediment and fish from these waters are relatively less contaminated than other freshwater and coastal/marine environments.