Environmental pollution by man-made Persistent Organic Chemicals (POCs) has been a serious global issue for over half a century. Exposure to POCs may result in health effects, including, endocrine disruption leading to birth defects, intellectual disability, low testosterone, childhood obesity, autism and attention deficit hyperactivity disorder (ADHD). Therefore, POCs have been the subject of an intensive regional, national, and international efforts to limit the production, use, and disposal of these chemicals. Since POCs are ubiquitous and recalcitrant, and cause long-term effects on wildlife and humans, trend monitoring studies are valuable in making clear the behavior and fate of these compounds and to protect our environment and living resources. The Pacific Basin is a unique geographical region representing tropical, temperate and polar zones. This region is home to 2/3 of the world’s population and consists of rapidly growing economies (countries) and highly developed countries. Due to this diversity of climatic and socio-economic conditions, environment and biota in different countries in this basin have varying degrees of environmental contamination and effects on wildlife and humans. The Pacific Rim countries play a pivotal role in governing global POC contamination and resulting harmful health effects. Because articles on POCs and their effect on environment and health are published in a large number of different journals, it is useful to have a book that includes original papers and reviews on the latest advances by well-known scientists in the field, especially focusing on the countries in the Pacific Rim.