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Computational estimation of pKa values
Wiley Interdisciplinary Reviews: Computational Molecular Science (2015)
  • Paul G. Seybold, Wright State University
  • George C. Shields, Bucknell University

The pKa of a compound is one of its most important properties as it defines the specific molecular forms that will prevail under different pH conditions. Accordingly, accurate means for computational estimation of this property are of particular interest. Two main techniques for this purpose have emerged: (1) a first principles approach that relies on basic physical concepts and requires high computational resources, but is independent of experimental input and (2) a linear free energy or quantitative structure–activity relationship (QSAR) approach that combines molecular structural and energetic descriptors with available experimental pKa data to reduce computational demand and yield good accuracy. In this overview, these methods are described and their advantages and limitations are noted

  • pKa calculation,
  • computational chemistry,
  • hydration,
  • protonation
Publication Date
Citation Information
Paul G. Seybold and George C. Shields. "Computational estimation of pKa values" Wiley Interdisciplinary Reviews: Computational Molecular Science Vol. 5 Iss. 3 (2015)
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