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Article
Adiposity is associated with early reduction in bone mass in pediatric inflammatory bowel disease
Endocrinology/Diabetes
  • Nithya Setty-Shah, University of Massachusetts Medical School
  • Louise S. Maranda, University of Massachusetts Medical School
  • Benjamin U. Nwosu, University of Massachusetts Medical School
UMMS Affiliation
Department of Pediatrics; Department of Quantitative Health Sciences; School of Medicine; Senior Scholars Program
Publication Date
1-21-2016
Document Type
Article
Abstract

Background: The effect of adiposity on bone mass in the early phases of inflammatory bowel disease (IBD) in children and adolescents is unclear.

Aims: To determine the role of adiposity on bone mass in the first 3 years of diagnosis of IBD.

Hypothesis: Increased adiposity will be associated with increased bone mass in both the controls and IBD subjects.

Setting: University tertiary institution.

Methods: Height-adjusted bone mineral density (BMD) z-scores of 25 subjects, age 13.97 ± 2.70y, diagnosed with IBD for < 4 years were compared to 24 controls, age 13.65 ± 2.60y. Overweight was defined as BMI of ≥85th but <95th percentile, and obesity as BMI ≥95thpercentile. Severity of IBD was determined by the Pediatric Crohn’s Disease Activity Index and Lichtiger Colitis Activity Index.

Results: Prior to stratification by BMI criterion, height-adjusted BMD z-scores were non-significantly lower in IBD subjects vs. controls for both the femoral neck (-0.8 ± 1.1 vs. -0.06 ± 1.1, p=0.070) and lumbar vertebrae (-0.4 ± 1.2 vs. 0.2 ± 1.2, p=0.086). Following stratification, height-adjusted BMD z-scores were significantly lower in the overweight/obese IBD subjects vs. overweight/obese controls for femoral neck (-0.9 ± 0.9 vs. 0.3 ± 1.3, p=0.032); and non-significantly lower for the lumbar spine z-score (-0.4 ± 1.6 vs. 0.5 ± 1.3, p=0.197). BMD z-score had no relationship with the duration of disease, steroid therapy, and the severity of disease.

Conclusion: Adiposity was associated with reduced bone mass in the early phases of IBD, but with increased bone mass in the controls.

Keywords
  • ulcerative colitis,
  • Crohn’s disease,
  • bone mineral density,
  • adiposity,
  • inflammation
Rights and Permissions
This is a PDF file of an unedited manuscript that has been accepted for publication and posted with a 12 month embargo as allowed by the publisher's author rights policy at https://www.elsevier.com/about/company-information/policies/sharing.
DOI of Published Version
10.1016/j.nut.2016.01.004
Source

Setty-Shah N, Maranda L, Nwosu BU. Adiposity is associated with early reduction in bone mass in pediatric inflammatory bowel disease. Nutrition. 2016 Jul-Aug;32(7-8):761-6. doi: 10.1016/j.nut.2016.01.004. PubMed PMID: 27138109. Link to article on publisher's site

Comments

Nithya Setty-Shah participated in this study as a medical student as part of the Senior Scholars research program at the University of Massachusetts Medical School.

Related Resources
Link to article in PubMed
PubMed ID
27138109
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 4.0
Citation Information
Nithya Setty-Shah, Louise S. Maranda and Benjamin U. Nwosu. "Adiposity is associated with early reduction in bone mass in pediatric inflammatory bowel disease" Vol. 32 Iss. 7-8 (2016)
Available at: http://works.bepress.com/benjamin_nwosu/43/