Skip to main content
Article
Centromeric heterochromatin assembly in fission yeast--balancing transcription, RNA interference and chromatin modification
Chromosome Research (2012)
  • Benjamin J. Alper
  • Brandon R. Lowe
  • Janet F. Partridge
Abstract
Distinct regions of the eukaryotic genome are packaged into different types of chromatin, with euchromatin representing gene rich, transcriptionally active regions and heterochromatin more condensed and gene poor. The assembly and maintenance of heterochromatin is important for many aspects of genome control, including silencing of gene transcription, suppression of recombination, and to ensure proper chromosome segregation. The precise mechanisms underlying heterochromatin establishment and maintenance are still unclear, but much progress has been made towards understanding this process during the last few years, particularly from studies performed in fission yeast. In this review, we hope to provide a conceptual model of centromeric heterochromatin in fission yeast that integrates our current understanding of the competing forces of transcription, replication, and RNA decay that influence its assembly and propagation.
Keywords
  • Heterochromatin,
  • Fission Yeast,
  • Centromeres,
  • RNAi
Publication Date
2012
DOI
10.1007/s10577-012-9288-x
Citation Information
Benjamin J. Alper, Brandon R. Lowe and Janet F. Partridge. "Centromeric heterochromatin assembly in fission yeast--balancing transcription, RNA interference and chromatin modification" Chromosome Research Vol. 20 Iss. 5 (2012) p. 521 - 534
Available at: http://works.bepress.com/benjamin_alper/22/