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Article
Evaluating amyloid beta (Aβ) 1-40 degradation by capillary electrophoresis.
Methods in Molecular Biology (2013)
  • Benjamin J. Alper
  • Walter K. Schmidt
Abstract
Here, we describe a capillary electrophoresis method for evaluating proteolysis of the amyloid beta peptide (Aβ) 1-40. This method is suitable for kinetic studies, demands little specialized equipment, and consumes only small quantities of a commercially available substrate whose physiological accumulation is thought to underlie the development of Alzheimer's disease.
Keywords
  • Amyloid beta peptides,
  • proteolysis,
  • insulin-degrading enzyme,
  • kinetics,
  • capillary electrophoresis
Publication Date
2013
DOI
10.1007/978-1-62703-296-4_19
Citation Information
Benjamin J. Alper and Walter K. Schmidt. "Evaluating amyloid beta (Aβ) 1-40 degradation by capillary electrophoresis." Methods in Molecular Biology Vol. 984 (2013) p. 263 - 273
Available at: http://works.bepress.com/benjamin_alper/20/