The healthcare processes and technologies in United States have improved significantly; however, there remains an issue of inefficient usage of available services in healthcare service delivery system at rural and urban locations, which appears to go wider as years goes by. The past research indicates that, practitioners of systems engineering have tried to solve this issue for separate units of the hospital, in different states, generating a need for overall healthcare system integration. In this paper, we propose the use of a Model Based Systems Engineering (MBSE) methodology to understand the complexities in healthcare service delivery system at urban and rural locations. It focuses on the interaction and collaboration among various stakeholders, healthcare service delivery system entities and patients in USA.