"Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals" by U. Sharma

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Article

Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals

Science (2016)

U. Sharma
C. C. Conine
J. M. Shea
A. Boskovic
A. G. Derr
X. Y. Bing
C. Belleannee
A. Kucukural
R. W. Serra
F. Sun
L. Song
B. R. Carone, Rowan University
E. P. Ricci
X. Li
L. Fauquier
M. J. Moore
R. Sullivan
C. C. Mello
M. Garber
O. J. Rando

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Abstract

Paternal dietary conditions in mammals influence the metabolic phenotypes of offspring. Although prior work suggests the involvement of epigenetic pathways, the mechanisms remains unclear. Two studies now show that altered paternal diet affects the level of small RNAs in mouse sperm. Chen et al. injected sperm transfer RNA (tRNA) fragments from males that had been kept on a high-fat diet into normal oocytes. The progeny displayed metabolic disorders and concomitant alteration of genes in metabolic pathways. Sharma et al. observed the biogenesis and function of small tRNA-derived fragments during sperm maturation. Further understanding of the mechanisms by which progeny are affected by parental exposure may affect human diseases such as diet-induced metabolic disorders.

Disciplines

Genetics and Genomics

Publication Date

January 22, 2016

DOI

10.1126/science.aad6780

Citation Information

U. Sharma, C. C. Conine, J. M. Shea, A. Boskovic, et al.. "Biogenesis and function of tRNA fragments during sperm maturation and fertilization in mammals" Science Vol. 351 Iss. 6271 (2016) p. 391 - 396
Available at: http://works.bepress.com/benjamin-carone/3/