Article
The Total Syntheses of JBIR-94 and Two Synthetic Analogs and Their Cytotoxicities Against A549 (CCL-185) Human Small Lung Cancer Cells
Tetrahedron Letters
Document Type
Article
Publication Date
11-4-2019
Publisher
Elsevier Ltd
Creative Commons License
Creative Commons Attribution-Noncommercial-No Derivative Works 4.0
Disciplines
Abstract
We here disclose the total syntheses of the natural polyphenol JBIR-94 and two nonnatural analogs, whose structures are of interest for their bioactivity potential as radical scavengers. Although we initially attempted this by dually acylating both of putrecine’s amine nitrogens in a single pot, our endeavors with this method (which has been successfully reported by other groups) proved ineffectual. We accordingly opted for the lengthier approach of acylating each amine individually, which gratuitously prevailed and also aligns with separate literature precedent. Moreover, we here share our analysis of these target compounds’ cytotoxicities and IC50 values against A549 (CCL-185) human small lung cancer cells.
Citation Information
Cathy L. Mangum, Mica B. Munford, Alyssa B. Sam, Sandra K. Young, Jeremy T. Beales, Yagya Prasad Subedi, Chad D. Mangum, Tanner J. Allen, Miranda S. Liddell, Andrew I. Merrell, Diana I. Saavedra, Becky L. Williams, Nicole Evans, Joseph L. Beales, and Michael A. Christiansen, The total syntheses of jbir-94 and two synthetic analogs and their cytotoxicities against a549 (ccl-185) human small lung cancer cells, Tetrahedron Letters 61 (2020), no. 1, 151360.