Background: Heart failure (HF) is the leading cause of death in the western world and new and innovative treatments are urgently needed. Aldosterone (Aldo) is one of several cardio-toxic hormones, whose levels are increased in ...

Aldosterone mediates many of the physiological and pathophysiological/cardio-toxic effects of angiotensin II (AngII). Its synthesis and secretion from the zona glomerulosa cells of the adrenal cortex, elevated in chronic heart failure (HF), is induced by ...

Specific tumor cell interactions with basement membrane (type IV) or fibrillar (types I–III) collagen have been shown previously to represent a regulatory step in metastasis [Nat. Rev. Cancer3, 422 (2003)]. Interestingly, numerous tumor cell receptors, ...

16,17-seco-3-Methoxyestra-1,3,5(10),16-tetraen-17-al undergoes intramolecular nitrone 1,3-dipolar cycloaddition with both hydroxylamine and N-methylhydroxylamine to produce a single isoxazolidine isomer in each case. The ring-closures of the hydrazones and the aldazine derived from the secoaldehyde lead to fused ...

The project focuses on investigating the synthesis of 2,2’-bipyridine adducts for potential future use as ligands in novel organometallic ruthenium complexes. The bipyridine building blocks, due to their excellent bidentate ligands with complexing abilities, will ...

The purpose of this project is to confirm the specific sites where the G protein receptor kinase 5 (GRK-5) mediated phosphorylation of the mineralocorticoid receptor (MR) of aldosterone takes place.The significance of the study stems ...

The project focuses on the preparation of 2,2’-bipyridine adducts for future use as ligands in novel organometallic ruthenium complexes. The first specific aim of the project includes utilizing substituted versus un-substituted bromo pyridines to explore ...

The focus of this investigation is to aid the development of a new advanced synthetic organic chemistry course, aiming for the development of possible synthetic routes of aromatic systems. Through a guided inquiry approach, students ...

A new, upper level synthetic organic chemistry course is being developed utilizing a guided inquiry approach. This particular project is focused on developing the potential library of target carbonyl compounds and corresponding simple starting molecules.Figure ...

Adiponectin, a protein hormone, has been shown to play a role in preventing the development of atherosclerosis, a common cardiovascular disease. Altering some of the amino acids in adiponectin can provide beneficial effects towards that ...