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Article
Effects of ketamine and magnesium on the minimum alveolar concentration of isoflurane in goats
American Journal of Veterinary Research (2006)
  • P Queiroz-Castro
  • Christine Egger
  • M A Redua
  • Barton W Rohrbach, Dr., University of Tennessee - Knoxville
  • Sherry Cox
  • Thomas Doherty
Abstract

Objective - To evaluate the effects of ketamine, magnesium sulfate, and their combination on the minimum alveolar concentration (MAC) of isoflurane (ISO-MAC) in goats. Animals - 8 adult goats. Procedures - Anesthesia was induced with isoflurane delivered via face mask. Goats were intubated and ventilated to maintain normocapnia. After an appropriate equilibration period, baseline MAC (MACB) was determined and the following 4 treatments were administered IV: saline (0.9% NaCl) solution (loading dose [LD], 30 mL/20 min; constant rate infusion [CRI], 60 mL/h), magnesium sulfate (LD, 50 mg/kg; CRI, 10 mg/kg/h), ketamine (LD, 1 mg/kg; CRI, 25 g/kg/min), and magnesium sulfate (LD, 50 mg/kg; CRI, 10 mg/kg/h) combined with ketamine (LD, 1 mg/kg; CRI, 25 g/kg/min); then MAC was redetermined. Results - Ketamine significantly decreased ISOMAC by 28.73.7%, and ketamine combined with magnesium sulfate significantly decreased ISOMAC by 21.14.1%. Saline solution or magnesium sulfate alone did not significantly change ISOMAC. Conclusions and Clinical Relevance - Ketamine and ketamine combined with magnesium sulfate, at doses used in the study, decreased the end-tidal isoflurane concentration needed to maintain anesthesia, verifying the clinical impression that ketamine decreases the end-tidal isoflurane concentration needed to maintain surgical anesthesia. Magnesium, at doses used in the study, did not decrease ISOMAC or augment ketamine's effects on ISOMAC.

Keywords
  • anaesthesia anaesthetics isoflurane ketamine magnesium sulfate pharmacodynamics pharmacokinetics potency goats anesthesia anesthetics drug action magnesium sulphate mechanism of drug action Capra Bovidae ruminants Artiodactyla mammals vertebrates Chordata animals ungulates eukaryotes
Disciplines
Publication Date
2006
Citation Information
P Queiroz-Castro, Christine Egger, M A Redua, Barton W Rohrbach, et al.. "Effects of ketamine and magnesium on the minimum alveolar concentration of isoflurane in goats" American Journal of Veterinary Research Vol. 67 Iss. 12 (2006)
Available at: http://works.bepress.com/barton_rohrbach/59/