The moderating effect of situational factors on the relationship between role ambiguity, job satisfaction, and effectiveness was tested in a sample of 138 nurses. Results indicated that the negative relationships generally reported between role ambiguity, satisfaction, and effectiveness were less substantial for individuals who perceived higher levels of interdepartmental information flow, decision making involvement, and teamwork in their units. It is suggested that variations in organizational structure may be an important strategy for reducing the negative impact of role ambiguity.