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About Barry Waterhouse

The longstanding interest (35 years) of my laboratory has been the role of monoamine transmitter systems, particularly norepinephrine (NE) and serotonin (5HT) pathways, in brain function and behavior. My most important contribution to the field has been advancing the idea that NE and 5HT operate as neuromodulatory agents in the CNS, i.e. modulating responses of target neurons and neural circuits to non-monoamine synaptic inputs, rather than acting as conventional transmitters conveying specific details of moment to moment information. This work has relied upon in vivo and in vitro electrophysiological approaches, immunohistochemical and tract tracing anatomical studies, pharmacological investigation of receptor-mediated transmitter actions, and behavioral paradigms to examine whole organism outcomes of monoamine-dependent brain functions. The data we generated in our early studies of NE actions provided the platform for numerous theories of operation of the locus coeruleus-NE system as the brain network responsible for alerting, orienting, and responding to salient internal and external (environmental) cues.

Positions

Present Professor and Chair, Rowan University Rowan University School of Osteopathic Medicine
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1994 - 2016 Professor, Drexel University College of Medicine ‐ Department of Neurobiology and Anatomy
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2014 - 2015 Interim Director, Division of Biomedical Science Programs, Drexel University College of Medicine ‐ Graduate School of Biomedical Sciences and Professional Studies
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2014 - 2015 Vice Dean, Drexel Univeristy College of Medicine ‐ Graduate School of Biomedical Sciences and Professional Studies
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2006 - 2014 Vice Dean, Drexel University College of Medicine ‐ Biomedical Graduate and Postgraduate Studies
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2001 - 2006 Associate Dean, Drexel University College of Medicine ‐ Biomedical Graduate, Postgraduate and Professional Studies
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1999 - 2004 Vice Chair, Drexel University College of Medicine ‐ Department of Neurobiology and Anatomy
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1994 - 1998 Director, Drexel University College of Medicine ‐ Neuroscience Graduate Program
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1992 - 1994 Professor, Hahnemann University ‐ Department of Physiology and Biophysics
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1989 - 1994 Director, Hahnemann University ‐ Graduate Program in Physiology and Biophysics
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1988 - 1994 Founding Director, Hahnemann University ‐ Neuroscience Graduate Program
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1987 - 1992 Associate Professor, Hahnemann University ‐ Department of Physiology and Biophysics
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1982 - 1987 Assistant Professor, The University of Texas Health Science Center ‐ Department of Cell Biology
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1980 - 1982 Instructor, The University of Texas Health Science Center ‐ Department of Cell Biology
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Curriculum Vitae



Research Interests


Grants

2017 - Present Impact of Repetitive Mild Traumatic Brain Injury (TBI) on Attention and Catecholamine Efflux in Prefrontal Cortex
New Jersey Commission on Brain Injury Research - CBIR17PIL007
$172,800
2016 - Present Noradrenergic Modulation of Early Stage Sensory Signal Processing and Performance of a Signal Detection Task
National Institutes of Health - R01 MH110417-01
Role: PI
$1,250,000
2015 - Present HIV gp120: Prefrontal Cortical Dysfunction and Propensity for Drug Abuse
NIH/National Institute on Drug Abuse - R01 DA041309-01
Role: PI
$1,809,155
2014 - Present Heterogeneous Properties of LC Efferents to Modality-specific Terminal Fields
National Institute of Mental Health (NIMH) - 1R01MH101178-01A1
Role: PI
$1,250,000
2004 - 2016 Locus Coeruleus Function and Methylphenidate Action
NIH/National Institute on Drug Abuse - 5R01DA017960
Role: PI
$1,125,000
2012 - 2015 HIV gp120 and Prefrontal Cortical Function
NIH/National Institute of Mental Health - R21 - MH097623-01
Role: PI
$275,000
2013 Phenotypic Diversity of Neurons Modulating Executive Function in ADHD
CURE – PA Tobacco Funds
Role: Co-Investigator
$92,000
2010 - 2012 Cortical Norepinephrine and Adolescent Executive Function
National Institute of Mental Health - 1R21MH087921
$400,000
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Professional Service and Affiliations

2013 - Present Brain Research, Senior Editor
1995 - Present College on Problems of Drug Dependence, Member
Present American College of Neuropsychopharmacology, Member 1996-2015; Fellow 2015-present
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Honors and Awards

  • 2014 Julian Marsh, MD – Faculty Scholar Award Drexel University College of Medicine for Excellence in Scientific Research, Outstanding Teaching Skills and Consistent High Quality Leadership
  • 2013 Goldberger-Boyne-Levine Award Department of Neurobiology and Anatomy Drexel University College of Medicine for Leadership of the Graduate Programs at Drexel University College of Medicine
  • 2013 Outstanding Faculty Contribution to “Discovery”, Drexel University College of Medicine Research Day Drexel University College of Medicine
  • 2010 Educator Award Philadelphia Chapter of the Society for Neuroscience

Education

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1979 - 1982 Scholar of the Biological Humanics Foundation, University of Texas Health Science Center - Dallas
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1977 - 1980 NIH Post-Doctoral Fellow, University of Texas Health Science Center - Dallas ‐ Cell Biology and Anatomy
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1977 Ph.D., Temple University School of Medicine ‐ Pharmacology
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1971 B.S., Muhlenberg College ‐ Biology
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Research Works (5)