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Article
Cell death in the thymus-it’s all a matter of contacts
Seminars in Immunology (2003)
  • Barbara A. Osborne, University of Massachusetts - Amherst
Abstract
Apoptosis, or programmed cell death, plays a critical role in shaping the T cell repertoire, deleting unproductive as well as potentially autoreactive T cells. Our understanding of how thymocyte apoptosis is regulated is continually evolving, as new essential modulators of this process are discovered. A conundrum that remains, however, is how signaling through essentially the same receptors and cascades evokes distinct biological responses: death by neglect, positive or negative selection. We hypothesize that the immunological synapse (IS) may be critical to transducing survival signals during thymocyte development, and suggest that factors affecting IS assembly may also influence T cell selection.
Disciplines
Publication Date
June, 2003
Citation Information
Barbara A. Osborne. "Cell death in the thymus-it’s all a matter of contacts" Seminars in Immunology Vol. 15 Iss. 3 (2003)
Available at: http://works.bepress.com/barbara_osborne/71/