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Transcriptional control of T cell development
Current Opinion in Immunology (2000)
  • Barbara A. Osborne, University of Massachusetts - Amherst
Transcriptional control of T cell development is a complex and rapidly moving area of investigation. Recent advances reveal critical roles for several transcription factors in T cell commitment, differentiation and selection. In particular, new roles for E proteins as well as members of the Notch signaling pathway have been described. Additionally, a unique function of Ikaros in chromatin remodeling reveals a novel mechanism by which transcriptional control may be exerted.
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Barbara A. Osborne. "Transcriptional control of T cell development" Current Opinion in Immunology Vol. 12 (2000)
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