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Presentation
Assessment of Diet in Patients with Inflammatory Bowel Disease: A Collaboration of Behavioral and Basic Scientists
Community Engagement and Research Symposia
  • Barbara C. Olendzki, University of Massachusetts Medical School
  • Aparna Kohli, University of Massachusetts Medical School
  • Effie Olendzki, University of Massachusetts Medical School
  • YuShuan (Cindy) Lai, University of Massachusetts Medical School
  • Ana Maldonado-Contreras, University of Massachusetts Medical School
Start Date
3-3-2017 8:00 AM
Document Type
Poster
Description

Introduction: Clinical research to develop treatment for inflammatory bowel disease (IBD) is focusing on a nutritional regimen restricting certain carbohydrates while incorporating the use of an optimal diet that includes pre- and probiotic foods. Current assessments are not able to measure elements of this nutritional regimen, thus we developed a food frequency questionnaire (FFQ). This FFQ will be utilized in a prospective study of IBD patients following an anti-inflammatory diet (IBD-AID) developed by us and used clinically at UMASS. We will track the bacterial communities inhabiting the microbiome of patients to determine diet-dependent changes, and their relation with patient wellbeing.

Objectives: 1) Develop an FFQ capable of identifying dietary components important to IBD: prebiotics, probiotics, beneficial nutrient intake, and avoidance of certain foods. 2) Determine diet-dependent changes of the gut microbiome.

Hypothesis: This study will show the microbiome of patients adopting the IBD-AID converge to one or more healthy 'enterotype' signatures, as compared to a non-IBD-AID control group.

Experimental design: Patients record daily FFQ. Foods and food groups (270) are categorized and grouped according to criteria of interest. Each food has a referent by which the patient can compare their own consumption. A scoring system satisfying dietary guidelines and components of the IBD-AID will be utilized. Twice per week patients collect stool samples for microbiome analysis. Microbiome composition and ecological metrics are compared to identify components influenced by the IBD-AID, and to separate bacterial 'enterotype' signatures of patients before, during and after diet intervention. We are currently recruiting patients.

Keywords
  • IBD,
  • inflammatory bowel disease,
  • diet,
  • Anti-inflammatory Diet for Inflammatory Bowel Disease (IBD-AID)
Creative Commons License
Creative Commons Attribution-Noncommercial-Share Alike 3.0
Citation Information
Barbara C. Olendzki, Aparna Kohli, Effie Olendzki, YuShuan (Cindy) Lai, et al.. "Assessment of Diet in Patients with Inflammatory Bowel Disease: A Collaboration of Behavioral and Basic Scientists" (2017)
Available at: http://works.bepress.com/barbara_olendzki/82/