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Dietary Magnesium Intake Improves Insulin Resistance among Non-Diabetic Individuals with Metabolic Syndrome Participating in a Dietary Trial
University of Massachusetts Medical School Faculty Publications
  • Jinsong Wang, University of Massachusetts Medical School
  • Gioia M. Persuitte, University of Massachusetts Medical School
  • Barbara C. Olendzki, University of Massachusetts Medical School
  • Nicole M. Wedick, University of Massachusetts Medical School
  • Zhiying Zhang, University of Massachusetts Medical School
  • Philip A. Merriam, University of Massachusetts Medical School Worcester
  • Hua Julia Fang, University of Massachusetts Medical School
  • James Carmody, University of Massachusetts Medical School
  • Gin-Fei Olendzki, University of Massachusetts Medical School
  • Yunsheng Ma, University of Massachusetts Medical School
UMMS Affiliation
Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Quantitative Health Sciences
Date
9-27-2013
Document Type
Article
Abstract
Many cross-sectional studies show an inverse association between dietary magnesium and insulin resistance, but few longitudinal studies examine the ability to meet the Recommended Dietary Allowance (RDA) for magnesium intake through food and its effect on insulin resistance among participants with metabolic syndrome (MetS). The dietary intervention study examined this question in 234 individuals with MetS. Magnesium intake was assessed using 24-h dietary recalls at baseline, 6, and 12 months. Fasting glucose and insulin levels were collected at each time point; and insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). The relation between magnesium intake and HOMA-IR was assessed using linear mixed models adjusted for covariates. Baseline magnesium intake was 287 +/- 93 mg/day (mean +/- standard deviation), and HOMA-IR, fasting glucose and fasting insulin were 3.7 +/- 3.5, 99 +/- 13 mg/dL, and 15 +/- 13 muU/mL, respectively. At baseline, 6-, and 12-months, 23.5%, 30.4%, and 27.7% met the RDA for magnesium. After multivariate adjustment, magnesium intake was inversely associated with metabolic biomarkers of insulin resistance (P < 0.01). Further, the likelihood of elevated HOMA-IR (>3.6) over time was 71% lower [odds ratio (OR): 0.29; 95% confidence interval (CI): 0.12, 0.72] in participants in the highest quartile of magnesium intake than those in the lowest quartile. For individuals meeting the RDA for magnesium, the multivariate-adjusted OR for high HOMA-IR over time was 0.37 (95% CI: 0.18, 0.77). These findings indicate that dietary magnesium intake is inadequate among non-diabetic individuals with MetS and suggest that increasing dietary magnesium to meet the RDA has a protective effect on insulin resistance.
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Citation: Wang J, Persuitte G, Olendzki BC, Wedick NM, Zhang Z, Merriam PA, Fang H, Carmody J, Olendzki G-F, Ma Y. Dietary Magnesium Intake Improves Insulin Resistance among Non-Diabetic Individuals with Metabolic Syndrome Participating in a Dietary Trial. Nutrients. 2013; 5(10):3910-3919. doi: 10.3390/nu5103910. Link to article on publisher's site

Copyright 2013 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Related Resources
Link to Article in PubMed
Keywords
  • UMCCTS funding
PubMed ID
24084051
Citation Information
Jinsong Wang, Gioia M. Persuitte, Barbara C. Olendzki, Nicole M. Wedick, et al.. "Dietary Magnesium Intake Improves Insulin Resistance among Non-Diabetic Individuals with Metabolic Syndrome Participating in a Dietary Trial" Vol. 5 Iss. 10 (2013) ISSN: 2072-6643 (Linking)
Available at: http://works.bepress.com/barbara_olendzki/64/