From monitoring traffic and parking to manipulating the tiniest of cells, or from spreading the scope of participatory democracy to defining the optimal limits of government, new technologies are leading to revolutionary interactions in public policy and governance. These innovations have grabbed the attention of some of Santa Clara University’s finest scholars. Since 1999, the Center for Science, Technology, and Society (CSTS), through its Research Grant Program, has funded 26 faculty scholars in a variety of disciplines in Arts and Sciences, Business, Law, and Engineering. These grant recipients have produced books, articles, and conference papers. This issue of STS NEXUS presents the work of five CSTS grant recipients whose works address one of the key issues of the day—the mutual interaction of technology, governance, and public policy.