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Baoyu Chen
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Assistant Professor of Biochemistry, Biophysics and Molecular Biology
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Assistant Professor of Biochemistry, Biophysics and Molecular Biology,
Iowa State University
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Biochemistry, Biophysics, and Structural Biology
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Articles
Book Chapters
Articles
(13)
Article
A two-step actin polymerization mechanism drives dendrite branching
Neural Development (2021)
Rebecca Shi, Daniel A. Kramer, Baoyu Chen and Kang Shen
Background: Dendrite morphogenesis plays an essential role in establishing the connectivity and receptive fields of neurons during the development of ...
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Article
HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory ...
Science (2020)
Sarah A. Cook, William A. Comrie, Morgan Similuk, Andrew J. Oler, et al.
Immunodeficiency often coincides with hyperactive immune disorders such as autoimmunity, lymphoproliferation, or atopy, but this coincidence is rarely understood on ...
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Article
A Dendritic Guidance Receptor Complex Brings Together Distinct Actin Regulators ...
Developmental Cell (2018)
Wei Zhou, Xintong Dong, Timothy R. Broederdorf, Ao Shen, et al.
Proper morphogenesis of dendrites plays a fundamental role in the establishment of neural circuits. The molecular mechanism by which dendrites ...
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Article
Rac1 GTPase activates the WAVE regulatory complex through two distinct ...
eLife (2017)
Baoyu Chen, Hui-Ting Chou, Chad A. Brautigam, Wenmin Xing, et al.
The Rho GTPase Rac1 activates the WAVE regulatory complex (WRC) to drive Arp2/3 complex-mediated actin polymerization, which underpins diverse cellular ...
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Article
Fat2 acts through the WAVE regulatory complex to drive collective ...
Journal of Cell Biology (2016)
Anna Julia Squarr, Klaus Brinkmann, Baoyu Chen, Tim Steinbacher, et al.
Directional cell movements during morphogenesis require the coordinated interplay between membrane receptors and the actin cytoskeleton. The WAVE regulatory complex ...
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Article
Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate ...
Developmental Cell (2014)
Xing Judy Chen, Anna Julia Squarr, Raiko Stephan, Baoyu Chen, et al.
Ena/VASP proteins and the WAVE regulatory complex (WRC) regulate cell motilityby virtue of their ability to independently promote actin polymerization. We demonstrate ...
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Article
Local F-actin Network Links Synapse Formation and Axon Branching
Cell (2014)
Poh Hui Chia, Baoyu Chen, Pengpeng Li, Michael K. Rosen, et al.
Axonal branching and synapse formation are tightly linked developmental events during the establishment of synaptic circuits. Newly formed synapses promote branch initiation ...
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Article
The WAVE Regulatory Complex Links Diverse Receptors to the Actin ...
Cell (2014)
Baoyu Chen, Klaus Brinkmann, Zhucheng Chen, Chi W. Pak, et al.
The WAVE regulatory complex (WRC) controls actin cytoskeletal dynamics throughout the cell by stimulating the actin-nucleating activity of the Arp2/3 complex at distinct membrane ...
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Article
Phase transitions in the assembly of multivalent signalling proteins
Nature (2012)
Pilong Li, Sudeep Banjade, Hui-Chun Cheng, Soyeon Kim, et al.
Cells are organized on length scales ranging from ångström to micrometres. However, the mechanisms by which ångström-scale molecular properties are ...
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Article
Engagement of Arginine Finger to ATP Triggers Large Conformational Changes ...
Structure (2010)
Baoyu Chen, Tatyana A. Sysoeva, Saikat Chowdhury, Liang Guo, et al.
The NtrC-like AAA+ ATPases control virulence and other important bacterial activities through delivering mechanical work to σ54-RNA polymerase to activate transcription from σ54-dependent genes. ...
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Article
ADPase activity of recombinantly expressed thermotolerant ATPases may be caused ...
The FEBS Journal (2009)
Baoyu Chen, Tatyana A. Sysoeva, Saikat Chowdhury, Liang Guo, et al.
Except for apyrases, ATPases generally target only the γ‐phosphate of a nucleotide. Some non‐apyrase ATPases from thermophilic microorganisms are reported ...
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Article
Regulation and action of the bacterial enhancer-binding protein AAA+ domains
Biochemical Society Transactions (2008)
Baoyu Chen, Tatyana A. Sysoeva, Saikat Chowdhury and B. Tracy Nixon
Bacterial EBPs (enhancer-binding proteins) play crucial roles in regulating cellular responses to environmental changes, in part by providing efficient control ...
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Article
ATP Ground- and Transition States of Bacterial Enhancer Binding AAA ...
Structure (2007)
Baoyu Chen, Michaeleen Doucleff, David E. Wemmer, Sacha De Carlo, et al.
Transcription initiation by the σ54 form of bacterial RNA polymerase requires hydrolysis of ATP by an enhancer binding protein (EBP). We present SAS-based solution structures of the ATPase domain of the ...
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Book Chapters
(1)
Contribution to Book
Biochemical Reconstitution of the WAVE Regulatory Complex
Methods in Enzymology (2014)
Baoyu Chen, Shae B. Padrick, Lisa Henry and Michael K. Rosen
The WAVE regulatory complex (WRC) is a 400-KDa heteropentameric protein assembly that plays a central role in controlling actin cytoskeletal ...
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