Nanoscale morphology of polyanhydride copolymersMacromolecules
AbstractThe microphase separation in polyanhydride random copolymers composed of 1,6-bis(p-carboxyphenoxy)hexane and sebacic acid is described. Though the copolymers are random, the monomers are sufficiently long and the segment-segment interaction parameter is sufficiently high to promote microphase separation when the copolymer is rich in one component. Solid-state NMR spin diffusion experiments and synchrotron small-angle X-ray scattering are used to discern the length scales of the microphase separation. Both techniques reveal a nanostructure with domain sizes less than 25 Ã…. This nanostructure is compared to approximate calculations of chain dimensions based on a random coil model and discussed in the context of the rational design of these materials for drug delivery applications.
Copyright OwnerAmerican Chemical Society
Citation InformationMatthew J. Kipper, Sheng-Shu Hou, Soenke Seifert, Papannan Thiyagarajan, et al.. "Nanoscale morphology of polyanhydride copolymers" Macromolecules Vol. 38 Iss. 20 (2005) p. 8468 - 8472
Available at: http://works.bepress.com/balaji_narasimhan/14/