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An Immediate Hemolytic Transfusion Reaction Due To Anti-C And A Delayed Hemolytic Transfusion Reaction Due To Anti-Ce+e: Hemoglobinemia, Hemoglobinuria And Transient Impaired Renal Function.
Vox sanguinis
  • Lyndall Molthan
  • Theodore J Matulewicz, MD, Lehigh Valley Health Network
  • Bala Carver, MD, Lehigh Valley Health Network
  • Edward J Benz
Publication/Presentation Date
A patient with phenotype R2r and anti-C has a hemolytic transfusion reaction (HTR) with hemoglobinemia and hemoglobinuria which occurred within 2 h of receiving an R1r transfusion. Transient impaired renal function ensued. A patient with phenotype R2R2 and anti-Ce+e had the same experience on day 4 after receiving three R1r and one rr units. 2 other patients, 1 R2r with anti-C who received one R1r unit and the other R2R2 with anti-Ce+e who received two R1r units, showed no clinical evidence of HTR. Both anti-C antibodies were entirely IgG while both anti-Ce+e antibodies initially were predominantly IgM. IgG subclassing was unsuccessful and red blood cell-mononuclear phagocyte assays were normal. These cases occurred from 1979 to 1981.
Document Type
Citation Information

Molthan L; Matulewicz TJ; Bansal-Carver B; Benz EJ, Vox Sanguinis [Vox Sang], ISSN: 0042-9007, 1984; Vol. 47 (5), pp. 348-53; Publisher: Blackwell Science