This paper is focused on feasible autonomous control strategies for Generation IV very high temperature reactors (VHTRs)-based systems for hydrogen production. Various burnable poison distributions and fuel compositions are considered. In particular, utilization of transuranium nuclides (TRUs) in VHTRs is explored as the core selfstabilization approach. Both direct cycle and indirect cycle energy conversion approaches are discussed. It is assumed that small-scale VHTRs may be considered for international deployment as grid-appropriate variable-scale self-contained systems addressing emerging demands for hydrogen. A Monte Carlo-deterministic analysis methodology has been implemented for coupled design studies of VHTRs with TRUs using the ORNL SCALE 5.1 code system. The developed modeling approach provides an exactgeometry 3D representation of the VHTR core details properly capturing VHTR physics. The discussed studies are being performed within the scope of the U.S. DOE Nuclear Energy Research Initiative project on utilization of higher actinides (TRUs and partitioned minor actinides) as a fuel component for extended-life VHTR configurations. © 2009 by ASME.