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Targeting the immune system to treat hypertension: Where are we?
Current opinion in nephrology and hypertension
  • Jennifer L. Gooch, Philadelphia College of Osteopathic Medicine
  • Avadhesh C. Sharma, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
9-1-2014
Disciplines
Abstract
PURPOSE OF REVIEW: Research over the past decade has significantly deepened our understanding of mechanisms that drive the development of hypertension. In particular, a novel paradigm of inflammation as a common mediator of cardiovascular and kidney disease has emerged. This review will summarize the role of the immune system in cardiovascular disease, explore some of the most promising new therapeutic directions and consider their potential as new treatments for hypertension. RECENT FINDINGS: Recent data continue to demonstrate that targeting the immune system can prevent hypertension in a variety of experimental models. Tempering the enthusiasm for a long-awaited new approach to treating hypertension is decades of clinical data, showing that classic immunosuppression regimens are associated with significant side-effects - including cardiovascular disease - that effectively preclude their use in the setting of chronic hypertension. New, more specific therapies are being developed that target cytokines including IL-17, IL-6 and TNFα. SUMMARY: Preclinical data convincingly demonstrate a key role for the immune system and specific cytokine mediators. Several biotherapeutics targeting these pathways are on the market and more are in development. Side-effects, however, continue to resemble those of classic immunosuppressants, highlighting the challenge of translating these research advances into new therapies for hypertension. VIDEO ABSTRACT: Copyright © Lippincott Williams & Wilkins.
Comments

This article was published in Current opinion in nephrology and hypertension, Volume 23, Issue 5, Pages 473-479.

A video abstract is available for download.

The published version is available at http://dx.doi.org/10.1097/MNH.0000000000000052.

Copyright © 2014Wolters Kluwer.

Citation Information
Jennifer L. Gooch and Avadhesh C. Sharma. "Targeting the immune system to treat hypertension: Where are we?" Current opinion in nephrology and hypertension Vol. 23 Iss. 5 (2014) p. 473 - 479
Available at: http://works.bepress.com/avadhesh_sharma/3/