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Article
Pathogenesis and therapy of autoimmunity-induced dilated cardiomyopathy
Frontiers in Bioscience
  • P. Zhao
  • Avadhesh C. Sharma, Philadelphia College of Osteopathic Medicine
  • J. Ren
Document Type
Article
Publication Date
1-1-2009
Abstract
Myocarditis and dilated cardiomyopathy can potentially originate from autoimmune responses. Although genetic predisposition, viral infection, molecular mimicry, and oxidative stress are potential contributing factors to dilated cardiomyopathy, the underlying mechanism (s) has not been fully elucidated. Autoantibodies (AABs) against cardiotropic targets such as β-adrenergic receptors, mitochondria proteins, myosin, tropomyocin and actin as well as structural proteins such as laminin and desmin may participate in the development of dilated cardiomyopathy. These autoantibodies disrupt cardiac excitation-contraction coupling and activate immune response to initiate tissue injury through complement and circulatory immunocomplexes (CICs). These antibodies are present prior to the onset of dilated cardiomyopathy and may be used to predict the deterioration of cardiac function. Depletion of these cardiac-specific antibodies by extracorporeal immunoabsorption has been considered as a new and effective approach in the treatment of autoimmunity-induced dilated cardiomyopathy. In order to better understand the pathogenesis and therapeutic remedy against this myopathy, the present review will summarize the manifestation and key signaling mechanisms involved in compromised cardiac contractile function during autoimmunity.
Comments

This article was published in Frontiers in Bioscience, Volume 14, Issue 5, Pages 1708-1715.

The published version is available at http://dx.doi.org/10.2741/3334.

Copyright © 2009 Frontiers in BioScience.

Citation Information
P. Zhao, Avadhesh C. Sharma and J. Ren. "Pathogenesis and therapy of autoimmunity-induced dilated cardiomyopathy" Frontiers in Bioscience Vol. 14 (2009) p. 1708 - 1715
Available at: http://works.bepress.com/avadhesh_sharma/29/