|Present||Chair and Professor, Philadelphia College of Osteopathic Medicine ‐ Department of Pharmaceutical Sciences|
|2010 - 2012||Ketamine-mediated modulation of NMDA and opioid receptors on activated platelets|
|2010 - 2011||Low-dose Ketamine (intraoperative) decreases postoperative opioid use|
|Oral Maxillofacial Research Foundation|
|Colleague(s): David Grogan (PI)|
|2006 - 2008||Endothelin converting enzyme in sepsis: cardiac function|
|2002 - 2004||Interactive Endothelin and Nitric Oxide Mechanisms in Myocardial Dysfunction in Sepsis|
|American Heart Association|
|Beginning Grant in Aid|
Professional Service and Affiliations
|2010 - 2012||President, Association of Scientists of Indian Origin in America||2009||Vice President, Association of Scientists of Indian Origin in America||Managing Editor, Frontiers in Bioscience, Encyclopedia in Bioscience|
- Cardiovascular Physiology
Scholarly Articles (74)
Bigendothelin-1 (1-21) fragment during early sepsis modulates tau, p38-MAPK phosphorylation ...
Molecular and cellular biochemistry (2005)
Earlier we have demonstrated that inhibition of endothelin biosynthesis ameliorates endotoxemia-induced inducible nitric oxide synthase (iNOS) activation and phosphorylation of ...
Bigendothelin-1 via p38-MAPK-dependent mechanism regulates adult rat ventricular myocyte contractility ...
Biochimica et Biophysica Acta - Molecular Basis of Disease (2005)
We tested the hypothesis that exogenous administration of the ET-1 precursor, bigET-1, would regulate adult rat ventricular myocyte (ARVM) contractility ...
Duration of streptozotocin-induced diabetes differentially affects p38-mitogen-activated protein kinase (MAPK ...
Cardiovascular Diabetology (2005)
Background: In the present study we tested the hypothesis that progression of streptozotocin (STZ)-induced diabetes (14-days to 28-days) would produce ...
Endothelin-converting enzyme-1-mediated signaling in adult rat ventricular myocyte contractility and ...
Journal of Molecular and Cellular Cardiology (2005)
We hypothesized that modulation of endothelin-converting enzyme-1 (ECE-1) activity would affect phosphorylation of p38-mitogen activated protein kinase (p38-MAPK) and potentiate ...
Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation ...
Molecular and cellular biochemistry (2004)
In the present study, we hypothesized that endotoxemia produces metalloendopeptidase (MEPD)-dependent generation of endothelin-1 (ET-1) and alters NOS expression correlating ...
Left ventricular mitogen activated protein kinase signaling following polymicrobial sepsis ...
Biochimica et Biophysica Acta - Molecular Basis of Disease (2004)
We hypothesized that sepsis during hyperglycemia would activate left ventricular (LV) mitogen activated protein kinase (MAPK) signaling mechanisms and modulate ...