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Article
A Model of Oxygen Diffusion in Absorbing Tissue
Mathematical Modelling
  • E. Tsiroyianni-Liapis
  • Athanasios I. Liapis, Missouri University of Science and Technology
  • Orrin K. Crosser, Missouri University of Science and Technology
  • G. G. Lipscomb
Abstract

A mathematical model is presented which describes the diffusion of oxygen in absorbing tissue, and numerical solutions of its partial differential equation are obtained by orthogonal collocation. The diffusion with absorption model accounts for the presence of a moving boundary which marks the furthest penetration of oxygen into the absorbing medium and also allows for an initial distribution of oxygen through the absorbing tissue. The model predictions may be used in the development of time variant radiation treatments of cancerous tumors, so that the dosage of radiation could be varied with the changing oxygen concentration. Simple expressions are also presented for evaluating the surface oxygen concentration, the rate of consumption of oxygen per unit volume of absorbing tissue, and the point of innermost oxygen penetration.

Department(s)
Chemical and Biochemical Engineering
Keywords and Phrases
  • Cancer,
  • Mathematical Model,
  • Nonbiological Model,
  • Oxygen Consumption,
  • Oxygen Diffusion,
  • Oxygen Tissue Level,
  • Radiotherapy,
  • Theoretical Study,
  • Therapy
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 1982 Elsevier, All rights reserved.
Publication Date
1-1-1982
Publication Date
01 Jan 1982
Disciplines
Citation Information
E. Tsiroyianni-Liapis, Athanasios I. Liapis, Orrin K. Crosser and G. G. Lipscomb. "A Model of Oxygen Diffusion in Absorbing Tissue" Mathematical Modelling (1982)
Available at: http://works.bepress.com/athanasios-liapis/16/