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Article
Neuroprotective effect of Myo/Nog cells in the stressed retina
Experimental eye research
  • Arturo Bravo Nuevo, Philadelphia College of Osteopathic Medicine
  • A. A. Brandli
  • Jacquelyn Gerhart, Philadelphia College of Osteopathic Medicine
  • J. Nichols
  • M. Pitts
  • C. Sutera
  • S. Assali
  • V. Scheinfeld
  • Mindy George-Weinstein, Philadelphia College of Osteopathic Medicine
  • et al.
Document Type
Article
Publication Date
1-1-2016
Disciplines
Abstract
Myo/Nog cells are essential for eye development in the chick embryo and respond to injury in adult tissues. These cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (mAb). In this study, we determined that Myo/Nog cells are present in low numbers in the retina of the mouse eye. G8-positive Myo/Nog cells were distinguished from neuronal, Müller and microglial cells that were identified with antibodies to calretinin, Chx10, glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1, respectively. In the neonatal retina, the number of Myo/Nog cells increased in parallel with cell death induced by transient exposure to hyperoxia. In this model of retinopathy of prematurity, depletion of Myo/Nog cells by intravitreal injection of the G8 mAb and complement increased cell death. These findings demonstrate that Myo/Nog cells are a distinct population of cells, not previously described in the retina, which increases in response to retinal damage and mitigate hypoxia-induced cell death.
Comments

This article was published in Experimental eye research, Volume 146, Issue , Pages 22-25.

The published version is available at http://dx.doi.org/10.1016/j.exer.2015.11.023.

Copyright © 2016 Elsevier.

Citation Information
Arturo Bravo Nuevo, A. A. Brandli, Jacquelyn Gerhart, J. Nichols, et al.. "Neuroprotective effect of Myo/Nog cells in the stressed retina" Experimental eye research Vol. 146 (2016) p. 22 - 25
Available at: http://works.bepress.com/arturo-bravo-nuevo/14/