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About Arthur M. Mercurio

Dr. Arthur M. Mercurio, Ph.D., is Professor in the Department of Molecular, Cell and Cancer Biology at the University of Massachusetts Medical School. His research is aimed at understanding mechanisms that enable epithelial-derived tumors (carcinomas) to invade surrounding tissue and progress to metastatic disease, with an emphasis on mechanisms that regulate epithelial and carcinoma differentiation. The loss of epithelial differentiation in populations of carcinoma cells enhances their aggressive behavior and rate of progression. His lab's research projects are based on the analysis and clinical behavior of poorly differentiated carcinomas. The goal is to identify mechanisms that account for the loss of differentiation and the highly aggressive behavior of these tumors, and to exploit these mechanisms to improve prognosis and therapy. Ongoing projects in the lab include studies on: integrin function and signaling; Epithelial-Mesenchymal Transition (EMT) in carcinoma differentiation and progression; VEGF signaling and carcinoma progression; and regulation of epithelial fate and carcinoma differentiation by estrogen receptors.


Present Professor, University of Massachusetts Medical School Department of Molecular, Cell and Cancer Biology

Curriculum Vitae


Research Interests

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Honors and Awards

  • GSBS Dean's Award for outstanding faculty contribution to graduate education, UMass Medical School (2013)
  • Distinguished Faculty Award for Outstanding Service (UMMS) (2008)
  • ‘Class of 88’ Speaker, Department of Biology, Middlebury College, Vermont (2003)
  • Honorary Professor (Signal Transduction & Tumor Progression), University of Copenhagen, Denmark (2001-2006)
  • American Cancer Society Faculty Research Award (1991-1996)
  • American Cancer Society Junior Faculty Research Award (1986-1989)

Contact Information

Department of Molecular, Cell and Cancer Biology
University of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Phone: 508-856-8676


Articles (137)