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Linked MRI signatures of the brain's acute and persistent response to concussion in female varsity rugby players.
NeuroImage: Clinical
  • Kathryn Y Manning
  • Alberto Llera
  • Gregory A Dekaban
  • Robert Bartha
  • Christy Barreira
  • Arthur Brown
  • Lisa Fischer
  • Tatiana Jevremovic
  • Kevin Blackney
  • Timothy J Doherty
  • Douglas D Fraser, Western University
  • Jeff Holmes, Western University
  • Christian F Beckmann
  • Ravi S Menon
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Acute brain changes are expected after concussion, yet there is growing evidence of persistent abnormalities well beyond clinical recovery and clearance to return to play. Multiparametric MRI is a powerful approach to non-invasively study structure-function relationships in the brain, however it remains challenging to interpret the complex and heterogeneous cascade of brain changes that manifest after concussion. Emerging conjunctive, data-driven analysis approaches like linked independent component analysis can integrate structural and functional imaging data to produce linked components that describe the shared inter-subject variance across images. These linked components not only offer the potential of a more comprehensive understanding of the underlying neurobiology of concussion, but can also provide reliable information at the level of an individual athlete. In this study, we analyzed resting-state functional MRI (rs-fMRI) and diffusion tensor imaging (DTI) within a cohort of female varsity rugby players (n = 52) through the in- and off-season, including concussed athletes (n = 21) who were studied longitudinally at three days, three months and six months after a diagnosed concussion. Linked components representing co-varying white matter microstructure and functional network connectivity characterized (a) the brain's acute response to concussion and (b) persistent alterations beyond clinical recovery. Furthermore, we demonstrate that these long-term brain changes related to specific aspects of a concussion history and allowed us to monitor individual athletes before and longitudinally after a diagnosed concussion.


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Citation Information
Kathryn Y Manning, Alberto Llera, Gregory A Dekaban, Robert Bartha, et al.. "Linked MRI signatures of the brain's acute and persistent response to concussion in female varsity rugby players." NeuroImage: Clinical Vol. 21 (2019) p. 101627 - 101627
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