Skip to main content
Article
Diabetes, Subclinical Atherosclerosis and Multiple Cardiovascular Risk Factors in Hard-to-Reach Asymptomatic Patients
Diabetes and Vascular Disease Research
  • Hadii M. Mamudu, East Tennessee State University
  • Arsham Alamian, East Tennessee State University
  • Timir Paul, East Tennessee State University
  • Pooja Subedi, East Tennessee State University
  • Liang Wang, East Tennessee State University
  • Antwan Jones, The George Washington University
  • Ali E. Alamin, East Tennessee State University
  • David Stewart, East Tennessee State University
  • Gerald Blackwell, Wellmont Health System
  • Matthew Budoff, University of California
Document Type
Article
Publication Date
8-16-2018
Description

Aim: To examine the association of cardiovascular disease risk factors with and their cumulative effect on coronary artery calcium in hard-to-reach asymptomatic patients with diabetes.

Methods: : A total of 2563 community-dwelling asymptomatic subjects from Central Appalachia participated in coronary artery calcium screening at a heart centre. Binary variable was used to indicate that coronary artery calcium was either present or absent. Independent variables consisted of demographic and modifiable risk factors and medical conditions. Descriptive statistics and multinomial logistic regression analyses were conducted.

Results: : In total, 55.8% and 13.7% of study participants had subclinical atherosclerosis (coronary artery calcium ⩾1) and diabetes, respectively. The presence of coronary artery calcium was higher in subjects with diabetes (68.5%) than those without (53.8%). Compared to subjects without diabetes with coronary artery calcium = 0, obesity, hypertension, hypercholesterolaemia and smoking increased the odds of the presence of coronary artery calcium (coronary artery calcium score ⩾1) regardless of diabetes status; however, with larger odds ratios in subjects with diabetes. Compared to subjects without diabetes with coronary artery calcium score = 0, having 3, 4 and ⩾5 risk factors increased the odds of presence of coronary artery calcium in subjects with diabetes by 14.06 (confidence interval = 3.26–62.69), 32.30 (confidence interval = 7.41–140.82) and 47.12 (confidence interval = 10.35–214.66) times, respectively.

Conclusion: : There is a need for awareness about subclinical atherosclerosis in patients with diabetes and more research about coronary artery calcium in subpopulations of patients.

Citation Information
Hadii M. Mamudu, Arsham Alamian, Timir Paul, Pooja Subedi, et al.. "Diabetes, Subclinical Atherosclerosis and Multiple Cardiovascular Risk Factors in Hard-to-Reach Asymptomatic Patients" Diabetes and Vascular Disease Research (2018) p. 1 - 9 ISSN: 1479-1641
Available at: http://works.bepress.com/arsham-alamian/64/