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Antibacterial and cytotoxic activities of the metabolites isolated from a Penicillium strain
Pharmaceutical Science and Research
  • Arm R. Amin, Marshall University
  • A. Jabbar
  • M. A. Rashid
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Three antibiotics (RA-1, RA-2 and RA-3) were isolated from the chloroform extract of the fermentation broth of a Penicillium strain of an unidentified species. These compounds exhibited a significant in vitro antibacterial activity against both gram-positive and gram-negative organisms. The MIC values for RA-1, RA-2 and RA-3 were also determined against Bacillus subtilis, Shigella sonnei and Escherichia coli. The chloroform extract also showed strong cytotoxicity in brine shrimp lethality assay.


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Citation Information
A.R.M. Ruhul Amin, A. Jabbar and M.A. Rashid, 2003. Antibacterial and Cytotoxic Activities of the Metabolites Isolated from a Penicillium Strain. Pakistan Journal of Biological Sciences, 6: 1365-1367.