This report provides operational guidance to maximize the impact of investments on nutrition outcomes for women and young children. The recommendations in this document build on evidence to date on issues of malnutrition, with the aim of providing concrete guidance on how to mainstream nutrition into agriculture, social protection, and health. The document is composed of five modules, including an introduction, an economic analysis of the relationship between poverty, economic growth and nutrition, and one module for each of the aforementioned focus sectors. Accompanying briefs for the agriculture, social protection and health modules are also available and serve as a summary of their corresponding chapters in the full guidance note. The objectives of the nutrition sensitive social protection are: 1) target activities to the most nutritionally vulnerable populations such as pregnant women and children less than 24 months; 2) include nutrition education and counseling activities within social protection interventions to increase household awareness of care giving and health seeking behaviors; 3) integrate nutrition services into social protection interventions; and 4) reduce the acute and long-term negative financial impacts of external financial, price, and weather shocks by scaling up programs in times of crises and by targeting shock-affected areas. Evidence-based interventions to address each objective, along with implementation considerations, are presented as options to integrate nutrition interventions in health investment and policies. To date, the scaling up nutrition framework has been endorsed by over 100 partners worldwide and 30 developing countries have committed to scaling up nutrition. Leaders of these countries are prioritizing nutrition as an investment in their people's growth, and recognizing nutrition as an investment in economic and social development to strengthen their nations.