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Article
Aflatoxins and Hepatitis B, C Viral Associated Hepatocarcinogenesis
Journal of Cell Science & Therapy
  • Humaira Qureshi, Aga khan University
  • Syed Shayan Ali, Aga khan University
  • Mazhar Iqbal, Aga khan University
  • Anwar Ali Siddiqui, Aga khan University
  • Naveed Ahmed Khan, Aga khan University
  • Saeed S Hamid, Aga khan University
Publication Date
9-29-2014
Document Type
Article
Abstract

Hepatocellular carcinoma is a serious human disease with fatal consequences. The most distressing aspect of hepatocellular carcinoma is the limited improvement in mortality (mortality rate of more than 90%). At present, the underlying molecular mechanisms are not well understood and treatment options are often of limited efficacy. This review presents our current understanding of the burden of hepatocellular carcinoma on human health, pathogenesis and pathophysiology, and molecular mechanisms associated with the disease, as well as our knowledge of the physical barriers, cellular mechanisms and molecular elements that may be targets for therapeutic interventions and/ or the development of preventative measures. As the proposed findings present a major risk to public health, it is hoped that robust intervention measures will be introduced for aflatoxins monitoring and reduction in diet.

Citation Information
Humaira Qureshi, Syed Shayan Ali, Mazhar Iqbal, Anwar Ali Siddiqui, et al.. "Aflatoxins and Hepatitis B, C Viral Associated Hepatocarcinogenesis" Journal of Cell Science & Therapy (2014)
Available at: http://works.bepress.com/anwar_siddiqui/8/