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Phenotypes of Alpha 1 Antitrypsin in Karachi, Pakistan
Journal Of Pakistan Medical Association
  • Anjum Shahid, Jinnah Postgraduate Medical Centre, Karachi.
  • Anwar Ali Siddiqui, Aga khan University
  • Sarwar i J Zuberi, Jinnah Postgraduate Medical Centre, Karachi
  • Mohammad Waqar, Aga khan University
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Objective: To determine serum level of the protease inhibitor, to identify phenotypes and determine their frequencies. Study Design: A prospective study. Setting: PMRC Research Centre, JPMC and the Aga Khan University Hospital Karachi. Subjects: Healthy aduIts without history ol peptic ulcer disease and a normal endoscopy. Methodology: Quantitive measurement of serum alpha 1 AT was carried out by radial immunodiffusion. phenotyping by iso-electric focusing and confirmation of phenotypes by immunofixation and DNA analysis technique. Results:Serum alpha I AT was low in 13.4% of the subjects. Ni MM phenotype predominated followed by SZ SS, MZ and ZZ. DNA diagnosis accurately resolved the phenotypes as S and Z. Conclusion: Frequency by phenotype associated with total and intermediate deficiency is less in the population
Citation Information
Anjum Shahid, Anwar Ali Siddiqui, Sarwar i J Zuberi and Mohammad Waqar. "Phenotypes of Alpha 1 Antitrypsin in Karachi, Pakistan" Journal Of Pakistan Medical Association (2000)
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