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Latent activity of curcumin against leishmaniasis in vitro
Biological and Pharmaceutical Bulletin
  • Danish Saleheen, Aga khan University
  • Syed Atif Ali, Aga khan University
  • Khalid Ashfaq, Aga khan University
  • Anwar Ali Siddiqui, Aga khan University
  • Ajmal Agha, Aga khan University
  • Muhammad Masoom Yasinzai, Aga khan University
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In this study the anti-proliferative effect of curcumin (curcuma longa) that is the active ingredient of ground dried rhizome has been studied against three local and three reference leishmanial strains, Leishmania major, Leishmania tropica and Leishmania infantum (Pakistani isolate). Curcumin has shown an average IC50 of 5.3mM against promastigotes of various leishmanial strains which is much lower as compared with pentamidine that is one of the basic treatments against leishmaniasis. The main draw back attributed to these assays performed on promastigotes is the heterogeneity of results compared with those obtained with intracellular amastigotes or with in vivo effect. We also tested activity of curcumin against axenic amastigote like cells (AALC) of L. major strain (MHOM/PK/88/DESTO). Curcumin proves to be far more potent then pentamidine against AALC which further strengthens the fact about its leishmaniacidal activity.

Citation Information
Danish Saleheen, Syed Atif Ali, Khalid Ashfaq, Anwar Ali Siddiqui, et al.. "Latent activity of curcumin against leishmaniasis in vitro" Biological and Pharmaceutical Bulletin Vol. 25 Iss. 3 (2002) p. 386 - 389
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