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Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats.
Phytotherapy Research
  • Samra Bashir, Aga Khan University
  • Anwar Gilani, Aga Khan University
  • Anwar Ali Siddiqui
  • Shahid Pervez, Aga Khan University
  • Saeed R. Khan
  • Noor Jehan Sarfaraz, Aga Khan University
  • Abdul Jabbar Shahs
Publication Date
Document Type
Berberis vulgaris is a widely used plant for the treatment of urolithiasis. To evaluate its antiurolithic potential, the crude aqueous-methanol extract of Berberis vulgaris root bark (Bv.Cr) was tested in an animal model of urolithiasis, developed in male Wistar rats by adding 0.75% ethylene glycol in drinking water. Bv.Cr (50 mg/kg) inhibited CaOx crystal deposition in renal tubules and protected against associated changes including polyuria, weight loss, impaired renal function and the development of oxidative stress in kidneys. Activity-guided fractionation revealed the concentration of antiurolithic constituent(s) mainly in the aqueous fraction. These data, indicating the presence of antiurolithic activity in Berberis vulgaris root bark, rationalize its medicinal use for the treatment or urolithiasis.
Citation Information
Samra Bashir, Anwar Gilani, Anwar Ali Siddiqui, Shahid Pervez, et al.. "Berberis vulgaris root bark extract prevents hyperoxaluria induced urolithiasis in rats." Phytotherapy Research Vol. 24 Iss. 8 (2010) p. 1250 - 1255
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