Healthy male rabbits weighing about 1 Kg to 1.5 Kg were divided into 4 groups. Group-I fed on normal stock and 50 mg cholesterol per day. Blood cholesterol levels in different groups of male rabbits (controls, crude garlic treated, petroleum ether extract treated and ethanol extract treated) show a significant inhibitory effect on the rise of serum cholesterol level. Thus, it was found that the extracted oils which were believed to be in solvent extracts and crude garlic effectively prevent rise in serum cholesterol level. The crude garlic is more effective than petroleum ether and ethanol extracts. Ethanol was least effective in suppressing serum cholesterol concentration.