Although several studies have shown the potential great benefits of traffic-responsive plan selection (TRPS) control, time-of-day operation continues to be the primary method used to select patterns for signal control applications. This practice could be largely attributed to the minimal guidelines available on the setup of the TRPS mode. An innovative framework for TRPS system setup is provided, and guidelines for implementing TRPS in a simplified manner are shown. The guidelines, developed at Texas Transportation Institute (TTI), use a comprehensive approach that incorporates a multiobjective evolutionary algorithm and a supervised discriminant analysis. Engineers can directly implement the guidelines presented as an initial design. Hardware-in-the-loop simulation is used to illustrate the performance of TTI’s TRPS configuration methodology.